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ea0041ep880 | Pituitary - Clinical | ECE2016

Predictive factors of surgical outcomes in acromegaly: what’s new in 2016?

Lapoirie Marion , Vasiljevic Alexandre , Rabilloud Muriel , Lapras Veronique , Chinezu Laura , Trouillas Jacqueline , Jouanneau Emmanuel , Raverot Gerald

Introduction: In the era of personalized patient management in acromegaly, transsphenoidal surgery remains a treatment of choice in cases where surgical cure can be expected. In order to better target these patients and to assess the risk of persistence/progression disease, we evaluated clinical, hormonal, radiological and pathological predictors of surgical outcome in acromegaly.Methods: A single-institution retrospective study from 2009 to 2015 was per...

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ePoster

ea0070aep617 | Pituitary and Neuroendocrinology | ECE2020

SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors

Castellnou Solene , Vasiljevic Alexandre , Lapras Veronique , Raverot Véronique , Alix Eudeline , Borson-Chazot Francoise , Jouanneau Emmanuel , Raverot Gerald , Hélène Lasolle

Context: Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 (USP8) mutations.Aims: To study the correlation between characteristics of corticotropinomasand SST5 expression/USP8 mutation status; to describe the response to pasireotide in 5 patients.Design: Retrospective cohort study.Metho...

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Endocrine Abstracts

Predictive factors of surgical outcomes in acromegaly: what’s new in 2016?

SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors

BiosciAbstracts